◄ Watanakunakorn Paper
A study by Watanakunakorn et al. is 1982 demonstrated that by the time-kill curve method, the combinations of vancomycin-gentamicin and vancomycin-tobramycin were shown to be syner- gistic against a majority of methicillin-susceptible and resistant strains of Staphylococcus aureus. Read More
◄ Minelli Paper
A study by Minelli et al. in 2011 demonstrated that PMMA specimens loaded with gentamicin (1.9%) + vancomycin (1.9%) combination showed a synergistic inhibitory effect against all 8 tested strains (no bacterial growth). As expected, bacterial adhesion was low in samples undergoing the highest antibiotic elution.
◄ Bakker Paper
A multi-center retrospective clinical study by Wouthuyzen-Bakker in 2018 found that in a 2-stage exchange procedure for PJI, adding a glycopeptide to the cement spacer reduces the rate of positive cultures during reimplantation and is associated with a lower failure rate due to CoNS afterward.